ABSTRACT
The genus enterococcus has 12 species of which, E faecalis and E faecium are most important in human infections. A progressive resistance to penicillin and ampicillin has been detected in these species. The aim of this work was to identify Enterococcus species isolated in a hospital and to study their antimicrobial susceptibility. We studied 209 Enterococcus species coming from patients admitted to a public hospital. Their susceptibility to penicillin, ampicillin, imipenem, vancomycin, tetracycline, chloramphenicol, ciprofloxacin, gentamycin and streptomycin was determined with the agar dilution technique. Eighty seven percent of species were E faecalis and 7,1 percent were E fecium, other isolated species were E hirae, E casseliflaws, E avium, E solitarius and E faecalis variant. 38 percent of these species were isolated from the urinary tract, 22 percent from the skin and 14 percent from surgical wounds. All E faecalis species were susceptible to penicillin, ampicillin, imipenem and vancomycin; 27,3 percent were susceptible to tetracycline, 54,7 percent to chloramphenicol and 80 percent to ciprofloxacin. Seventy three percent of E faecium species were susceptible to penicillin, 80 percent to ampicillin and 60 percent to imipenem. 62 percent of E faecalis and 42.4 percent of E faecium were resistant to streptomycin. It is concluded that the correct identification of Enterococcus species has therapeutic implications
Subject(s)
Enterococcus/pathogenicity , In Vitro Techniques , Penicillins/pharmacokinetics , Tetracycline/pharmacokinetics , Drug Resistance, Microbial , Vancomycin/pharmacokinetics , Ciprofloxacin/pharmacokinetics , Microbial Sensitivity Tests , Chloramphenicol/pharmacokinetics , Imipenem/pharmacokinetics , Enterococcus/isolation & purification , Enterococcus/drug effects , Ampicillin/pharmacokineticsABSTRACT
Se evalúa la sensibilidad de 28 cepas de Neisseria gonorrhoeae por la técnica de difusión en agar para cuatro antimicrobianos. Los resultados demuestran una alta resistencia a tetraciclina y penicilina con un 71,4% y 17,9% respectivamente. Frente a ciprofloxacina y cefotaxima todas las cepas estudiadas fueron sensibles
Subject(s)
Cefotaxime , Ciprofloxacin/pharmacokinetics , In Vitro Techniques , Microbial Sensitivity Tests , Neisseria gonorrhoeae/drug effects , Penicillins/pharmacokinetics , Tetracycline/pharmacokinetics , Drug Resistance, MicrobialSubject(s)
Anti-Bacterial Agents , Drug Prescriptions , Aminoglycosides/pharmacokinetics , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/antagonists & inhibitors , Anti-Bacterial Agents/adverse effects , Anti-Bacterial Agents/pharmacokinetics , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/toxicity , Anti-Bacterial Agents/therapeutic use , Cephalosporins/pharmacokinetics , Chloramphenicol/pharmacokinetics , Erythromycin/pharmacokinetics , Lincomycin/pharmacokinetics , Penicillins/pharmacokinetics , Rifampin/pharmacokinetics , Sulfamethoxazole/pharmacokinetics , Tetracycline/pharmacokinetics , Trimethoprim/pharmacokinetics , Vancomycin/pharmacokineticsABSTRACT
Se realiza la comparación de 3 lotes de tetraciclina tabletas, en dosis única, a través de un ensayo de bloques incompletos distribuidos al azar, aplicada a 6 voluntarios sanos en estado de ayunas, y se obtiene la biodisponibilidad relativa en sangre, así como los pérfiles de disolución de las tabletas. Se logran obtener buenos resultados in vivo-in vitro con las mismas, a fin de que puedan ser aplicados estos resultados como método de control de la calidad de este medicamento